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It is a non-hormonal approach: no IGF-1 or cortisol changes, no stimulant jitters, no appetite suppression
Moreover, while NfL correlates with disease activity and long-term prognosis, it has not yet been validated as a surrogate endpoint in clinical trials, limiting its utility in regulatory routes
S., Yu, W
10.1038/s41586-018-0316-7 125 KanarekN.PetrovaB.SabatiniD
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